Can we slow down or reverse our aging? Where should we look for the ‘elixir’ that will keep us young?

I have been observing some people who are active and strong despite their age, and I also have been reading about people in Okinawa, Japan who lived healthily beyond 100 years old. Yet, at the same time, we are surrounded with people who are frail and really struggling with life beyond 60 years old. What can I gather from this observation? What makes the difference between these elderly? Diet? Lifestyle?

Aging is a process that everyone must undergo in our phase of life at our own time and pace. However, it is a process that many of us understand very little about. Though it is easy to make a list of all the changes that come with age such as grey hair, memory loss, wrinkles, and muscle loss, do we really know what happens to our body? Where should we look for the elixir that will keep us young? Really, I am searching for one! Are you not?

You could spend hours reading online tips for the prevention of age-related diseases or the latest shortcuts to achieving a younger looking skin and body. However, there are many common misconceptions people of all ages have when it comes to aging gracefully. To promote healthy ageing, it must start with our cellular health.

Scientists can use the length of a telomere to determine the age of a cell and how many more replications it has left. At each end of a chromosome is a telomere which people will often compare to the plastic tips at the ends of a shoelace. As cellular division slows, it undergoes a progressive deterioration known as senescence, which we commonly refer to as aging. Cellular senescence explains why our organs and tissues begin to change as we grow older.

Cellular health automatically allows each of our cells to function, reproduce, and communicate properly. Cells get ample nourishment and protection and are capable of completing the thousands of processes necessary for total and complete health. However, the health of your cells declines as you age, which will affect your overall well-being. It is important to remember that your cells are the building blocks for every muscle, tissue, and organ in your body, so the first signs of aging actually start from your cells. Therefore, ageing must be tackled at cellular level to promote healthy and functional years of life.

When experts say cell health declines as you age, one thing they really mean is where Nicotinamide adenine dinucleotide (NAD+) levels drop. NAD+ is a coenzyme that is necessary in all living cells. NAD+ is a key player in many key cellular functions, from energy production, to circadian rhythm regulation, to DNA health. NAD+ is also crucial for the function of sirtuins, a family of proteins that regulate cellular health, enhances cellular repair mechanisms and promotes health and longevity.

Research shows that NAD+ levels decline with age. This means that cellular processes that rely on NAD+ may not be able to function as efficiently as we get older. Recent studies have revealed numerous roles of NAD+ metabolism on aging and longevity. In particular, an age-dependent decline in NAD+ levels have consistently been reported, possibly due to an imbalance in the synthesis and consumption of NAD+. Decreased levels of NAD+ are associated with aging, as well as several age-related diseases, including metabolic disorders, cancer and neurodegenerative diseases. Replenishment of NAD+ levels via administration of its precursors have been demonstrated to display beneficial effects against aging and age-related diseases.

However, NAD+ molecule is unstable and cannot be used as a supplement. For ages, scientists around the world have been looking for answers to the problem of decline in NAD+ level as we aged. Only now we may have found the answer to restore cellular NAD+ levels. They found that Nicotinamide Riboside (NR) would be a useful precursor to boost NAD+ levels. NR is a natural NAD+ precursor, a form of vitamin B3, and it is found to be well-tolerated and elevates NAD+ in healthy middle-aged and older adults. NR offers to provide an additional pathway for elevation of NAD+ levels.

Clinical studies have shown that NR exhibited beneficial effects in protection against aging and age-related diseases. It has been shown to promote longevity as well as improve healthspan. In age-related disease, in particular obesity, diabetes, and cardiovascular diseases, NR was able to decrease weight gain, improve glucose tolerance and reduce blood pressure, arterial stiffness, non‐alcoholic fatty liver disease and improve muscle functions.

At SOLLIFE, we decided to develop a drink that promotes health and longevity. We formulated ActivSol Vigo Gold consists of essential active ingredients which help to slow down the aging process. It comprises Nicotinamide Riboside, a compound which promotes health and longevity that we all need, coupled with black cumin and grape seed extracts, inulin and rice protein. All these ingredients are a good source of protein, fibre, antioxidants and properties that slowdowns the ageing process and promotes longevity to help you stay active and young.

At SOLLIFE, we care about your health, from the cellular level. So why not add a daily supplement into your health regime, that is backed by groundbreaking research. I am hoping that this could be the ‘elixir’ that I’m looking for! Common, try it today and share with us your experience!

Benefits of Vigo Gold:

  1. Reverse signs of aging and chronic illnesses, such as diabetes, heart disease, Alzheimer’s disease and vision loss.
  2. Strong anti-oxidative properties, able to repair damaged DNA.
  3. Promote growth of new cells and skin’s elasticity, help skin from looking aged.
  4. Boost memory by protecting brain cells.
  5. Reduce stiffness of blood vessels and blood pressure.
  6. Improve muscle function, help regain physical strength.
  7. Inulin is able to promote better digestive health, relieve constipation, promote weight loss and help reduce metabolic diseases.

References:

  1. Yaku, K., Okabe, K. and Nakagawa, T., 2018. NAD metabolism: Implications in aging and longevity. Ageing research reviews, 47, pp.1-17.
  2. Guan, Y., Wang, S.R., Huang, X.Z., Xie, Q.H., Xu, Y.Y., Shang, D. and Hao, C.M., 2017. Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner. Journal of the American Society of Nephrology, 28(8), pp.2337-2352.
  3. Verdin, E., 2015. NAD+ in aging, metabolism, and neurodegeneration. Science, 350(6265), pp.1208-1213.
  4. Yoshino, J., Mills, K.F., Yoon, M.J. and Imai, S.I., 2011. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice. Cell metabolism, 14(4), pp.528-536.
  5. Z. Yao, W. Yang, Z. Gao, P. Jia. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neurosci. Lett., 647 (2017), pp. 133-140
  6. Poljsak, B. and Milisav, I., 2016. NAD+ as the link between oxidative stress, inflammation, caloric restriction, exercise, DNA repair, longevity, and health span. Rejuvenation research, 19(5), pp.406-413.
  7. Zhou, C.C., Yang, X., Hua, X., Liu, J., Fan, M.B., Li, G.Q., Song, J., Xu, T.Y., Li, Z.Y., Guan, Y.F. and Wang, P., 2016. Hepatic NAD+ deficiency as a therapeutic target for non‐alcoholic fatty liver disease in ageing. British journal of pharmacology, 173(15), pp.2352-2368.
  8. Ryu, D., Zhang, H., Ropelle, E.R., Sorrentino, V., Mázala, D.A., Mouchiroud, L., Marshall, P.L., Campbell, M.D., Ali, A.S., Knowels, G.M. and Bellemin, S., 2016. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Science translational medicine, 8(361), pp.361ra139-361ra139.
  9. Aman, Y., Qiu, Y., Tao, J. and Fang, E.F., 2018. Therapeutic potential of boosting NAD+ in aging and age-related diseases. Translational Medicine of Aging, 2, pp.30-37.
  10. Martens, C.R., Denman, B.A., Mazzo, M.R., Armstrong, M.L., Reisdorph, N., McQueen, M.B., Chonchol, M. and Seals, D.R., 2018. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature communications, 9(1), pp.1-11.

Authors:

Brenda Yeong Huai En
BSc (Hons) Nutrition
Product Development Specialist
One Green Solution Sdn Bhd
Dato Nazlee Mohd Kamal, PhD.
Managing Director
One Green Solution Sdn Bhd

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